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Water Quality Branch U. The primary effort in preparing this bibliography was supplied by Melanie Donohue. Valuable clerical support was provided by Sharon Moore.

In additional aspects, the present invention provides compositions and kits comprising the compounds of the invention and methods for their use, for example, for the prevention or treatment of a cancer.

Hara donglingcao family Labiataeformerly known as Isodon rubescens, is a Chinese medicinal herb.

The aerial parts of R. Rubescensin A oridonin and rubescensin B ponicidin are two compounds identified in R. Both compounds have also been shown to be anti-angiogenic. II or a pharmaceutically or physiologically acceptable salt, solvate or hydrate thereof, wherein R2, R3, R4 and R10 are as defined above in formula I.

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III or a pharmaceutically or physiologically acceptable salt, solvate, or hydrate thereof, wherein Ac is acetyl. IV or a pharmaceutically or physiologically acceptable salt, solvate, or hydrate thereof, wherein R1, R2, R3 and R4 are each independently hydrogen, C1-C6 alkyl, Q.

In general, the composition is not a natural source of such compounds, such as anatomical parts of the Rabdosia rubescens plant. Alternatively, one or more purified diterpenoids or depsides can be used to make such compositions.

Such a composition can also be prepared, for example, by adding an amount of at least one diterpenoid or depside of the invention to a natural source or processed form of a natural source of the diterpenoid or depside of the invention. In one embodiment, the nutraceutical compositions and cosmetic compositions of the invention are prepared from natural sources.

In certain embodiments, the pharmaceutical composition comprises an effective amount of one or more compounds of the invention and a pharmaceutically acceptable carrier, diluent, vehicle or excipient. In some embodiments, the pharmaceutical composition is suitable for parenteral, transdermal, mucosal, nasal, buccal, rectal, sublingual or oral administration to a subject.

In certain embodiments, the methods comprise administering a prophylactically or therapeutically effective amount of a compound of the invention or composition thereof to the subject thereby preventing, treating, managing, or ameliorating the disorder.

In certain embodiments, the methods provide a beneficial result by managing symptoms of a disorder, or lessening discomfort associated with a symptom or disorder, e. In some embodiments, the proliferative disorder prevented, treated, managed, or ameliorated is a breast cancer, colon cancer, esophageal cancer, liver cancer, lung cancer, prostate cancer, pancreatic cancer, ovarian cancer, skin melanoma, or symptom thereof.

The methods are useful for relieving a symptom of inflammation in a subject, such as but not limited to redness, swelling, edema, excess warmth, allergic reactions; or lessening the discomfort associated with a symptom of inflammation.

The present invention also provides combination therapies and protocols. In some embodiments, the invention provides methods for the prevention or treatment of a cancer or symptom thereof comprising administering an effective amount of a compound selected from the group consisting of rubescensin M, rabdoternin A, rabdoternin B or rabdoternin C, thereby preventing or treating the cancer or symptom thereof.

In one aspect, the invention provides methods for inhibiting tumor growth. In some embodiments, the methods comprise administering a composition comprising a compound selected from the group consisting of rubescensin J, rebescensinrubscendepside, rubescensin M, rabdoternin A, rabdoternin B or rabdoternin C.

Unless stated otherwise, the terms are meant to encompass, and are not limited to, pharamceutical compositions, nutraceutical compositions, and cosmetic compositions.

For example, if the compound s can be obtained from a plant, the terms are not intended to encompass the plant or an anatomical part of the plant, however, a powder or a solvent extract of the plant or plant part s can be a composition of the invention.

The term also refers to compositions which have been prepared directly from that which occurs in the natural environment by a process that does not selectively remove or retain one or more specific compounds relative to the other different compounds.

Effect of rubscendepside on neoplastic transformation in JB6 cells. Effect of rubscendepside on HCTl 16 expression of phenotype. Effect of rubscendepside on HT expression of phenotype.

Effect of rubescensin J on neoplastic transformation in JB6 cells. Effect of rubescensin J on HCTl 16 expression of phenotype. Effect of rubescensin J on HT expression of phenotype. Effect of rubescensin M on neoplastic transformation in JB6 cells.

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Effect of rubescensin M on HT expression of phenotype. Effect of rabdoternin A on neoplastic transformation in JB 6 cells. Effect of rabdoternin A on HCTl 16 expression of phenotype. Effect of rabdoternin A on HT expression of phenotype. Effect of rabdoternin B on neoplastic transformation in JB6 cells.

Effect of rabdoternin B on HCTl 16 expression of phenotype. Effect of rabdoternin C on neoplastic transformation in JB 6 cells.Austronesian Comparative Dictionary. Proto-form indexes (click on a *proto-form for its cognate set). Preferably, a therapeutically effective of a therapy (e.g., a therapeutic agent) reduces the inflammation of a organ or tissue by at least 5%, preferably at least 10%, at least 15%, at least 20%, at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, or at least 99%, .

Sheet3 Sheet2 Sheet1 Excel_BuiltIn__FilterDatabase_1 Carlton McLendon, Inc.

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Furthermore the range of information could be deployed in a few simple effective displays that could help a lot. Take credit card information for example. Recordered there is the time and location of the person using the credit card as is the data from cash machines which also are reported to store video of the person taking out money.