Veterinary Resources This is a list of citations and summaries of veterinary research journal articles which are applicable to mitral valve disease and cavalier King Charles spaniels. This list is in chronological order, from to the current date, with the most recent additions added at the bottom of this page. Hyper-linked titles are linked to the actual articles which are available on-line.
Unsurprisingly, they found that all of these did, indeed, serve as predictors of a higher hazard of cardiac death. One surprise predictor of the likelihood of cardiac death was "Receiving a potent diuretic".
However, the rationale behind prescribing potent diuretics was not explored and some dogs without CHF might have inappropriately received diuretics. Sometimes it is frustrating to try to objectively summarize studies by RVC cardiology researchers because they tend to either overlook or intentionally hide the obvious and refuse to provide breed-specific data about cavalier King Charles spaniels.
This is another one of those times. Boswood, studied the effect of pre-heart failure administration of pimobendan on dogs, Boswood bother to provide any breed-specific data or findings about cavaliers. When we asked him to do so, his response was, in short, "No". Once again, here Dr.
Boswood fails to provide data singling out the cavalier -- data he surely has -- even though there were six times more cavaliers in this study than any other breed.
Not only that, but three of the seven organizations which assisted RVC in recruiting dogs were cavalier groups, the Cavalier Campaign, Cavalier Matters, and the Companion Cavalier club.
Surely their members expected some helpful information about their breed in the reported results. When you combine CKCSs with all other breeds in a study of this nature, you end up with a mess of unhelpful information for cavalier owners.
Italian researchers find serum iron decreases in MVD-affected dogs in heart failure stages. Brambilla studied the case records of 54 dogs, measuring their serum iron concentration SIC and iron-capacity factors. They did not find any significant differences in iron values between Stage B and Stage C dogs.
Thai study shows that moderate regular exercise can improve physical capacity in MVD-affected dogs in Stage B1. In an October articlea team of Thai veterinary researchers Saikaew Sutayatram [right], Chollada Buranakarl, Anusak Kijtawornrat, Kumpanart Soontornvipart, Pakit Boonpala, Prapawadee Pirintr tested six Beagles with Stage B1 mitral valve disease mitral regurgitation but no heart enlargementto determine the effects of "submaximal endurance training" by treadmill running and 6-minute walks, over a period of eight weeks.
It did not test dogs in Stage B2 heart enlarged or in Stage C in heart failure. The investigators report finding that the exercise: They concluded that, "supervised or moderate regular exercise that is within the individual physical capacity should be performed in subclinical MMVD dogs and dogs with low routine physical activity, in order to preserve or improve physical capacity and quality of life.
Visser devises new landmark x-ray measurement to diagnose enlargement of the left atrium in MVD-affected dogs. In an October articleUniv. Johnson have introduced a new, highly accurate x-ray measurement of the left atrium LA to determine if MVD-affected dogs have LA enlargement.
They call their measurement "vertebral left atrial size VLAS ". Technically, they describe the measurement as: For the purpose of this study, the carina was defined as the radiolucent circular or ovoid structure within the trachea that represented the bifurcation of the left and right mainstem bronchi.
Similar to the vertebral heart size method, a second line that was equal in length to the first was drawn beginning at the cranial edge of T4 and extending caudally just ventral and parallel to the vertebral canal Figure 1, below. The VLAS was defined as the length of the second line expressed in vertebral-body units to the nearest 0.
The investigators compared these x-ray measurements with echocardiographic measurements of the left atrium of each dog, using two standard echo images of the LA: AoSx and b long-axis LA: AoLx and short LA: Results also indicated that VLAS was a readily repeatable measurement, with a high level of agreement among measurements obtained by the same individual on multiple occasions as well as by multiple individuals.
This appears to be a monumental invention for diagnosing MVD-affected dogs in Stage B2 heart enlargement.
Now that enlargement is the point at which the EPIC Study recommends commencing treatment with pimobendan, the detection of enlargement of the LA is an important landmark in the progression and medication of MVD.
Using x-rays to measure the size of the heart and then compare that dimension to the same dog's vertebrae is nothing new. His system called for two measurements of the entire heart -- one of the width short axis and the other of the length long axis see image at right -- then combining those two measurements and comparing them to the dog's vertebrae to arrive at a total number.
Buchanan's initial intention was to use the VHS system for comparison purposes, starting with a "baseline" x-ray taken before any enlargement has been suspected, and then comparing that baseline to later x-rays to determine if the heart has begun to enlarge.
A problem with the VHS system is that neither the the short nor long axis measurement always took into account the fact that the LA, in the upper right corner of the x-rays, may be enlarging but not being included in those two measurements.
For example, see the image at left here, showing that the LA, outlined in red, is mostly excluded from the two standard VHS dimensions. Visser has figured out how to not only include the LA in the VHS system, but to focus solely upon it. Now, all of that praise aside, Dr.
Visser has fallen into the same trap that several other recent cardiology researchers have, which is to blindly rely upon baseless, arbitrary minimum echocardiographic measurements to define LA enlargement.The Molecular Repair of the Brain by Ralph C. Merkle; Xerox PARC Coyote Hill Road Palo Alto, CA [email protected] Please see the separate article on Information-Theoretic Death for a more recent treatment of this fundamental concept..
This article was published in two parts in Cryonics magazine, Vol.
15 No's 1 & 2, January and April Practical Geostatistics () was the third (and probably shortest) book ever published on geostatistics. Based on 7 years of teaching technical valuation to undergraduate and postgraduate mining engineers, examples were drawn from the author's consultancy experience.
The Medical Services Advisory Committee (MSAC) is an independent non-statutory committee established by the Australian Government Minister for Health in Subpart —Federal Supply Schedules Definitions.
As used in this subpart— “Ordering activity” means an activity that is authorized to place orders, or establish blanket purchase agreements (BPA), against the General Services Administration’s (GSA) Multiple Award Schedule contracts.
ii Acknowledgments Battelle, under the direction of the United States Environmental Protection Agency (EPA) through Scientific, Technical, Research, Engineering and Modeling Support (STREAMS).
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